Debate regarding evidence based medicine in current state focuses on basic philosophical as-sumptions of paradigm announced in 1992 by EBM Working Group. One of the topic in this debate is clinical reasoning in light of medical decision-making. Polish literature still lacks of comprehensive presentation in this theoretical fi eld. In current article I present overview of models of clinical reasoning. I begin from the debate of rationality distinguishing two positions called meliorism and panglosianism. Next I proceed to elaboration of three models for clinical reasoning in context of meliorists position. It gives an opportunity to look closer for inferential rules of clinical decision-making and as a result may be precious perspective for future re-search and medical education.