Purpose: The study’s purpose was to examine the management of agri-food enterprises’ resource-saving development to minimize potential imperfections in managing material and human resources and improve data quality.

Materials and methods: A combined analysis was used to display the potential relationships between the agri-food sector achievements and basic indicators of natural resources’ sustainability and resilience to risks. The analysis covered Ukraine, Romania, and Poland. The analysis allowed for developing a general management scheme, including a management transformation comparative description in the economic growth context.

Results: The study revealed that Ukraine is clearly not on the path to progress in manufacturing enterprises and agriculture, as most of its indicators do not meet global nutrition goals. At the same time, Ukraine remains an export-oriented country. Its agri-food enterprises’ activities focus on external markets, corresponding to the priorities of the country’s agricultural policy and sustainable development goals of the United Nations organization.

Conclusion: The obtained results provide knowledge about and understanding of processes that occur in the agri-food enterprises’ organizational structure in countries with different development levels. The awareness of these processes is crucial for effective enterprise management in the resource conservation context.