The intense development of nanotechnology in recent years poses the basic question about the safety of employees who work with nanomaterials. The study attempts to determine how employers should regulate health protection when working with nanoparticles. Employers should be aware of the importance of the risks associated with nanotechnology and their responsibility for worker health and safety. The study is a continuation of the author’s previous analyses of ways to regulate occupational safety and health in the use of nanomaterials. The author examines the theory of responsive regulation in the context of health and safety with nano-materials and the importance of dialogue in this regulatory process. The regulatory agencies should intervene in this area depending on the attainment of the assumed objectives of the law. The sense of responsibility for the effect could improve the quality of OH&S with nanomaterials.